Research
MAGIC vs. CROSS ICORG 10-14
Randomised Clinical Trial of Neoadjuvant and Adjuvant Chemotherapy (MAGIC Regimen) vs. Neoadjuvant Chemoradiation (CROSS Protocol) in Adenocarcinoma of the Oesophagus and Oesophago-gastric Junction
Spinal Cord Retreat ICORG 07-11
A Phase II Trial Evaluating the Efficacy of a Radio-Biological Based Re-Irradiation Strategy for Patients With Malignant Spinal Cord Compression
PEACE
A Phase III of ADT +/- Local RT +/- Abiraterone Acetate in Metastatic Hormone-naïve Prostate Cancer
ENZARAD
Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer
MAGIC vs. CROSS ICORG 10-14
Randomised Clinical Trial of Neoadjuvant and Adjuvant Chemotherapy (MAGIC Regimen) vs. Neoadjuvant Chemoradiation (CROSS Protocol) in Adenocarcinoma of the Oesophagus and Oesophago-gastric Junction
Spinal Cord Retreat ICORG 07-11
A Phase II Trial Evaluating the Efficacy of a Radio-Biological Based Re-Irradiation Strategy for Patients With Malignant Spinal Cord Compression
PEACE
A Phase III of ADT +/- Local RT +/- Abiraterone Acetate in Metastatic Hormone-naïve Prostate Cancer
ENZARAD
Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer
Publications / Presentations
Publications
Peer Reviewed
P Thirion, L O'Sullivan, A Clayton-Lea, C Small, O McArdle, P Kelly, I Parker, J O'Sullivan, D Hacking, C Collins, M Pomeroy, M Moriarty ICORG 05-03: Prospective Randomized Non-Inferiority Phase 3 Trial Comparing Two Radiation Schedules in Malignant Spinal Cord Compression not Proceeding with Surgical Decompression. Int J Radiat Oncol Biol Phys. 2/2014; 90(5):1263-4
L. O'Sullivan, A. Clayton-Lea, O. McArdle, M. McGarry, J. Kenny, M. Dunne, E. O'Shea, C. Small, M. Moriarty, P. Thirion. A prospective study of patients with impending spinal cord compression treated with palliative radiotherapy alone. Journal of Radiotherapy in Practice 09/2013; 12(03).
Pervez N, Small C, MacKenzie M, Yee D, Parliament M, Ghosh S, Mihai A, Amanie J, Murtha A, Field C, Murray D, Fallone G, Pearcey R. Acute toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):57-64. Epub
Roa W, Xing JZ, Small C, Kortmann R, Miriamanoff R, Okunieff P, Shibamoto Y, Jeremic B Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme. Expert Rev Anticancer Ther. 2009 Nov;9(11):1643-50.
Joseph KJ, Syme A, Small C, Warkentin H, Quon H, Ghosh S, Field C, Pervez N, Tankel K, Patel S, Usmani N, Severin D, Nijjar T, Fallone G, Pedersen J A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer. Radiat Oncol. 2009 Nov 4. [Epub ahead of print]
Joseph K.J, Alvi R, Skarsgard D, Tonita J, Pervez N, Small C, Tai P. Analysis of Health Related Quality of Life (HRQoL) of patients with clinically localized prostate cancer, one year after treatment with External Beam Radiotherapy (EBRT) alone vs. EBRT and High Dose Rate Brachytherapy (HDRBT), Radiat. Oncol. 2008; 3:20
Aherne N, Small C, McVey G, Fitzpatrick D, Armstrong J. Abnormal hCG levels in a patient with treated Stage I seminoma : a diagnostic dilemma. World J Surg Oncol. 2008; 6: 68
Kerhet A, Small C, Quon H, Riauka T, Schrader L, Greiner R, Yee D, McEwan A, Roa W. Application of Machine Learning Methodology for PET-Based Definition of Lung Cancer. Current Oncology 2010 Jan 17;1
Other
Kerhet, A., Small, C., Quon, H., Riauka, T., Greiner, R., McEwan, A., & Roa, W. Segmentation of Lung Tumours in Positron Emission Tomography Scans: A Machine Learning Approach. Artificial Intelligence in Medicine, 146.
Thirion P, Small C, Gillham C, Fitzpatrick D. Head and Neck radiotherapy: The role of conformal radiotherapy in reducing toxicity. ESTRO teaching course on Radiotherapy Treatment Planning: Principles and Practice 2007
Thirion P, Fitzpatrick D, Small C. Localised non-small cell lung Cancer, anatomy, pathology and treatment. ESTRO teaching course on Radiotherapy Treatment Planning: Principles and Practice 2007
Thirion P, Kelly P, Small C, Fitzpatrick D. Breast Cancer: Anatomy, pathology and treatment. ESTRO teaching course on Radiotherapy Treatment Planning: Principles and Practice 2007
Thirion P, Small C, McArdle O, Fitzpatrick D. Prostate Cancer: Anatomy, pathology and treatment. ESTRO Teaching Course on Radiotherapy Treatment Planning: Principles and Practice 2005
Thirion P, McArdle O, Small C, Fitzpatrick D. Head and Neck radiotherapy and toxicities. ESTRO Teaching Course on Radiotherapy Treatment Planning: Principles and Practice 2005
Posters
International Meetings
Functional outcome of patients with impending cord compression treated by palliative radiotherapy alone. L. O'Sullivan, A. Clayton-Lea, J. Kenny, M. Dunne, E. O'Shea, O. McArdle, C. Small, M. Moriarty, C. Collins, P. Thirion11th Biennial on Physics & Radiation Technology For Clinical Radiotherapy 8-12 May 2011 – London, UK
Severin D., Joseph K., Usmani N., Tankel K., Nijjar T., Small C., Hennig R., Gaetz E., Field C., Mihai A. Pilot Study of preoperative involved field radiotherapy in rectal cancer. ECCO/ESMO, Berlin September 2009, Berlin
S. Loewen, K. Joseph, C. Small, A. Syme, H. Warkentin, E. Gaetz, K. Tankel, D. Severin, N. Usmani, C. Field, T. Nijjar Tomotherapy in the treatment of anal cancer: acute toxicity data ECCO/ESMO, Berlin September 2009, Berlin
Small C., Chowdury R., Mackenzie M., Syme A., Field C., Pervez N. Is the dose we see the dose we get? Analysis of DVH’s using daily tomotherapy based MVCT contouring of prostate, bladder and rectum, to assess the actual dose received during treatment as opposed to planned DVH, ASTRO, September 2008, Boston
Chowdury R., Small C., Mackenzie M., Pervez N. Changes in 3T-MRI prostate volumes in high risk prostate cancer treated with hypofractionated radiation using dynamic IMRT and varying hormonal therapy duration, ASTRO, September 2008, Boston
Thirion P, McGarry M, Rangaswamy G, Small C, McArdle O, Clayton-Lea A: Prospective evaluation of the vital and functional outcome of patients diagnosed with MRI-defined malignant impending spinal cord compression treated by palliative radiotherapy alone. ESTRO, September 2008, Göteborg
Gunn O'Connor S, McCloy R, McCafferty B, Rangaswamy G, Small C, Keane G, Collins C, Clayton-Lea A, O'Shea E, Thirion P: ICORG 06-35: Prospective evaluation of PET-CT scan in patiens with non-operable or non-resectable NSCLC treated by radical 3-dimensional conformal radiation therapy. ESTRO, September 2008, Göteborg
McGarry M, Clayton-Lea A, Small C, McArdle O, Thirion P, Moriarty M: Challenges and issues in conducting clinical trials in palliative radiotherapy. ESTRO, September 2008, Göteborg
Small C., Thirion P., McArdle O., Planning study assessing the effectiveness of the addition of the thyroid block in the 3 field radiotherapy technique for breast cancer, RSNA, November 25-30 2007, Chicago
Quon H., Joseph K.J., Small C., Syme A., Warkentin H., Mackenzie M., Field C. Potential for reduced toxicity in the treatment of anal canal cancer: a dosimetric comparison of tomotherapy, 9-Field IMRT, and 3-D conformal radiation therapy techniques, ASTRO, October 28 – November 1 2007, Los Angeles
Clayton-Lea A., McArdle O., Moriarty M., Thirion P., Small C. Spinal cord compression versus impending spinal cord compression: prospective study of patient, Physics and Radiation Technology for Clinical Radiotherapy, September 8-13 2007, Barcelona, Spain